WebMar 15, 2024 · The protein expression of GRP78, Caspase-3, IRE1, p-IRE1, JNK1, CHOP, PERK, eIF2α, and ATF4 was detected by Western blotting. Results: The different exercise intensities could reduce the protein expression of ATF4, Bax, and hepatocyte apoptosis. Meanwhile, the antioxidant function and Bcl-2 were increased. WebApr 4, 2024 · IRE1 pathway: Through oligomerization and autophosphorylation, IRE1 is initiated and results in increased RNase activity. Activated IRE1 prompts splicing of a 26 …
IRE1α siRNA relieves endoplasmic reticulum stress …
WebOct 10, 2013 · a Negative siRNA and specific siRNAs against IRE1 and CHOP was transfected in Huh-7 and HepG-2 cell lines to knock down the expression IRE1 and CHOP. After cells were exposed to bufalin (80 nmol/l) for 48 h, the protein levels of Beclin-1, CHOP, IRE1, cleaved caspase-3 and LC3 conversion were validated. Web与模型组比较10%参元丹组中,Grp78(P<0. 01)及CHOP(P<0. 05)均有明显下降,10%空白血清组Grp78、CHOP较模型组无明显变化。 结论:参元丹可以通过减轻内质网应激减少心肌细胞的凋亡,保护心肌细胞。 how to setstate with a dynamic key name
Cerebral Glucose Metabolism and Potential Effects on …
WebHowever, IRE1 also induces selective cleavages within the X-box binding protein 1 (XBP1) resulting in CHOP signaling as reported in our study [62]. Prior studies conveyed that CHOP promotes the elevation of ER oxidoreduction 1α (ERO1α) expression which leads to hyper oxidization of ER lumen [63]. In the present study, the expression of ERO1α ... WebAug 1, 2014 · Although both the IRE-1 and ATF6 pathways can up-regulate CHOP, the PERK pathway predominates through selective up-regulation of translation of ATF4, which … Astragalus polysaccharide regulates brown adipogenic differentiation through miR … WebNov 9, 2007 · By contrast, PERK signaling, including translational inhibition and proapoptotic transcription regulator Chop induction, was maintained. When IRE1 activity was sustained artificially, cell survival was enhanced, suggesting a causal link between the duration of UPR branch signaling and life or death cell fate after ER stress. Key findings from ... notice end of contract