WebJun 20, 2000 · Arrest in G 2 /M was associated with a concomitant decrease in the percentage of cells in G 1 phase, with a smaller reduction in the S phase population (Table 1). Induction of G 2 /M arrest by BBL22 consistently was observed regardless of tumor type, hormone receptor status of breast cancer cells, or androgen-dependent or -independent …
Synchronization of Cultured Cells to G1, S, G2, and M Phases
WebThe anti-tumor activity of diosgenin, a new steroidal constituent present in fenugreek, on two human breast cancer cell lines, MCF-7 and Hs578T, was studied. Diosgenin treatment resulted in cell growth inhibition, cell cycle arrest, and apoptosis in concentration- and time-dependent manners in both cell lines. Western blot analyses of whole cell lysates for … WebMar 1, 2012 · During the G2 phase of the cell cycle, Cdk1/Cyclin B (also referred to as Cdc2/Cyclin B in Xenopus) complexes accumulate and are held inactive by phosphorylations on Thr14 and Tyr15 of Cdk1.These inhibitory phosphorylations are catalyzed by the Wee1 family kinases, namely, Wee1 and Myt1. 10,11 At the G2/M … onbase imagesoft
What are the good markers for G2/M phase of cell cycle?
WebMoreover, Ouabain greatly induced cell cycle arrest at G2/M phase in both A375 and SK-Mel-28 cells, and the migration of melanoma cells was also inhibited by ouabain treatment. Proliferation inhibition and apoptosis induction were the main features of most anticancer drugs in the clinic. As reported, ouabain exhibited double effects on cell ... WebG2/M transition (or mitotic entry) is the progression from G2-phase to M-phase (also referred to as “mitosis”) of the mitotic cell division cycle. Characteristics Eukaryotic cells … WebIn contrast to the lack of appreciable effect on the phosphorylation of ERK and p38 MAPK, activation of JNK was noted when K562 cells were exposed to IQDMA. Moreover, IQDMA-mediated G2/M phase arrest and apoptosis were reversed after treatment with the JNK-specific inhibitors, SP600125 and JNK inhibitor 1. onbase implementation